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demonstrated that high glucose significantly promotes TGF-1 secretion in HK-2 renal tubular cells, triggering ferroptosis via the TGF-1/Smad3 signaling pathway, while sleeve gastrectomy alleviates the symptoms and progression of diabetic kidney disease by downregulating this pathway [135]

HSCs contain approximately 50-80% of the whole body stores of retinoids (Blomhoff et al., 1990)

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Discontinue treatment if elevated liver-function tests persist or worsen, or if signs or symptoms of hepatic disease, such as jaundice, develop

TAMs are well-known parts of breast cancer microenvironment and most TAMs within TME are closely related to the M2-like phenotype, which participate in almost all metastatic processes, including local invasion, blood vessel intravasation, extravasation at distant sites and metastatic cell growth (287, 288).The hypoxic areas in tumors are related to the accumulation of macrophages, which assist tumor progression by producing angiogenic factors, mitogenic factors and cytokines related to tumor metastasis (289291)

doi: 10.1007/978-1-4419-8216-2_7 498 ManianFA