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J Tradit Chin Med (2016) 36:56477

91 The maladjustment of methionine and SAM metabolism has been well-accepted in ALD, while the effect of this maladjustment on downstream products has not been fully investigated

doi: 10.1038/cr.2015.68 71 YanJHorngT

doi: 10.1038/s41556-018-0178-0

This results in the cellular and extra-cellular accumulation of an increasing number of non-functional proteins that tend to form hydrophobic aggregates [117]