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p97/VCP is required for piecemeal autophagy of aggresomes

10.1002/advs.202417022 60 GiulianiC.Di DalmaziG.BucciI.NapolitanoG

Domain architecture analysis of putative glyoxalases Domain architecture of putative SbGLYI proteins was analysed to determine the presence of functional domains and to draw similarities in protein features between glyoxalases from sorghum and other plant species

Inhibition of GPX4/GSH or System Xc activity is considered a central mechanism in the induction of ferroptosis [16, 17]

This is in agreement with previous work indicating that TMZ resistance in glioma is associated with lower production of reactive oxygen species by the resistant cell line, 15 although this does not exclude the possibility of a scavenging action of GSH also for TMZ

Modulation of Inflammatory Pathways Persistent tendon pain is not always driven by inflammation alone, but inflammatory signaling can still play an important role, especially in the early stages of injury