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Furthermore, among the ORF3a homologs from -CoV (HCoV-229E), -CoV (SARS-CoV-2, SARS-CoV, and Middle East respiratory syndrome coronavirus (MERS-CoV)), and -CoV (IBV), SARS-CoV-2 ORF3a uniquely inhibited autophagy (Supplementary Fig

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The treatment was generally safe and well tolerated