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CS, Cigarette smoke

10.1016/j.tem.2012.01.001 Trends Endocrinol

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This hypothesis aligns with broader models of metallopeptide signaling, wherein metal-bound peptides operate as semiotic units chemical messages encoding both peptide sequence information and metal state data

There is evidence that all four subunits of GIRK channels are expressed at varying levels in the pancreas (Tanizawa et al., 1996), pancreatic islet cells (Yoshimoto et al., 1999), and insulinoma (Stoffel et al., 1995