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Silibinin restores the sensitivity of cisplatin and taxol in A2780-resistant cell and reduces drug-induced hepatotoxicity

doi: 10.1080/09553002.2018.1422871 9 MalouffTDMahajanAKrishnanSBeltranCSeneviratneDSTrifilettiDM

When the fixed black cumin oil was administered through PO or IP routes in mice and rats, the acute toxicity studies revealed LD 50 values of 28.8 ml/kg and 2.06 ml/kg, respectively