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[10], MNA exhibited no passive permeability in parallel artificial membrane permeability assay (PAMPA), which might partly explain the undesirable treatment effects of MNA in the control of body weight and blood glucose homeostasis

This phenomenon may be attributed to the differential regulation of tissue specificity

Annu Rev Biochem 85:161192

Persistent vomiting, severe nausea that prevents eating, diarrhea lasting more than a week, or any symptom that significantly impacts your daily functioning requires medical attention and likely a dose adjustment