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But we dont yet know exactly why

477 Insulin resistance or impaired signaling in diabetes activates FOXO-1 and PDK4, reducing mitochondrial glucose oxidation

Khachar, Vipul P

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The brain requires a great supply of oxygen and is one of the organs that produces large amounts of ROS, such as H 2 O 2 , superoxide anion, nitric oxide, peroxynitrite anion, hydroxyl and peroxyl radicals [58]

Emerging microbiome-based strategies in dairy cow: opportunities and challenges Growing evidence from microbiotaorgan axis studies indicates that dysbiosis-related disorders in dairy cows are driven by coordinated disturbances in microbial community structure and function across multiple organs, rather than by changes in individual taxa or metabolites