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The original Harding lab publications described rat studies showing: Improvement in cognitive performance in Morris water maze tasks (Wright et al

Diabetes Care 45 , 18331840 (2022)

The Lancet Gastroenterology & Hepatology

For example, hypervitaminosis A can be caused by taking one large dose of over 200 mg of vitamin A, or chronic use of more than 10 times the recommended daily intake ( Vitamin A toxicity may lead to serious complications, such as increased spinal fluid pressure, coma, and potentially fatal organ damage ( Additionally, taking megadoses of vitamin D more than 50,000 IU daily over long periods can lead to high blood levels of calcium (hypercalcemia), which can lead to death ( Overdosing on other vitamins can likewise cause potentially fatal side effects, such as liver damage