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Role of oxidants and antioxidants in the induction of AP-1, NF-kB, and glutathione S-transferase gene expression

2.6.1.5 Effects of SL on liver fibrosis A team of Chinese researchers reported that SL inhibited HSC activation and hepatic apoptosis and prevented the formation of mallory-denk bodies in the NASH liver when SL was orally administered to the male C57BL/6 mice which were fed a MCD diet for 8 weeks, and the effect was related to alteration of lipid metabolism-related gene expression, activation of the Nrf2 pathway and inhibition of the NF-B signaling pathway in the NASH liver (Ou et al., 2018)

Another formulation containing milk thistle extract was designed to protect the liver and prevent liver fibrosis

STAT3 dimers subsequently move to the nucleus and modulate cyclin D1 expression, influencing the G1/S transition in hepatocytes