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Common maintenance approaches include staying at the dose where you stabilized (often 1.0 to 1.7 mg), reducing by one dose level from your peak (e.g., from 2.4 mg to 1.7 mg), or finding the minimum dose that prevents weight regain while minimizing side effects

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For instance, when excluding both supplements and medications, those with a deficient-low B 12 status had a significantly increased risk of incident depressive symptoms (OR 165 (95 % CI 107, 254)

In older age, vitamin B12 absorption tends to be less efficient due to a range of health issues, including gastritis stomach lining inflammation and thinning but also because of decreased production of stomach secretions (EFSA, 2015

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Its chosen based on what each patient needs