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Control: saline 5.0 ml/kg b.w., i.p

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Table 39 Physical stability of the cagrilintide and semaglutide co-formulations with varying pH within the pH-range 5.5 to 6.0 Results for number of sub-visible particles are the mean of 3 replicates and has been rounded to nearest integer value (-) sampling not performed Table 40 Chemical purity (%) of cagrilintide in the cagrilintide and semaglutide co-formulations with varying pH within the pH-range 5.5 to 6.0 Concluding Remarks The results presented in tables 39 and 40 show that the physical and chemical stability of semaglutide and cagrilintide depend on the pH of the formulation: the highest pH results in the lowest cagrilintide purity after 28 days at 37C

Terreic acid is a quinone epoxide antibiotic and a potent Btk inhibitor, blocking the interaction between PKC and the PH domain of Btk.T Terreic acid also acts on HMC-1 human mast cell lysates, inhibiting the binding of GST-BtkPH to PKC with an IC50 of approximately 100 M