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[23] While the applicant submitted a separate comment stating there was no worsening in the safety profile for patients with false positive results, we continue to question the impact on patient outcomes when taking additional tissues that were false positives

However, under pathological conditions such as those in inflammatory arthritis and estrogen-deficient osteoporosis, the overproduction of ROS is often linked with excessive bone loss (Ashtar et al., 2020)

23, (2022), Abstract Spatially resolved phosphoproteomics reveals fibroblast growth factor receptor recycling-driven regulation of autophagy and survival: Watson, J., Ferguson, H

NAFLD appears to be more frequent in industrialized countries, its global prevalence is about 25% and varies across different geographical areas, being higher in Middle East and South America and lower in Africa (33)

Kurokawa et al., 2012, 2014b)

10.1038/s41467-017-00970-1 28 YouJ.-G.TsengW.-L