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Anaphylactic reactions to thiamine are exceedingly uncommon (estimated incidence well below 1 %), but they have been documented

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2 Interstitial fluid pressure The hydrostatic and osmotic pressure differences between the vasculature and the surrounding tissue move fluid out from the blood vessels to the interstitium, allowing the supply of nutrients and oxygen to the resident tissue cells [11]

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"Care should be taken to avoid overdosing, particularly during early pregnancy," Ms Krilich said