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This type of localization permits the analysis to be formed from an effectively larger dimensional space than could be determined by forming the transform operator directly from a linear combination of global perturbations, though each localized solution is still determined from a linear subspace that is limited by the ensemble size

The perpendicular diameters of the tumours were measured three times weekly using standard calipers and tumour volumes were calculated using the formula: 0.5 D d 2 , where D and d were the longest and shortest perpendicular diameters, respectively

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