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Silymarin downregulates MPO/MDA [534] and blocks the IL-6/STAT3 [535]-cell division cycle 25C (Cdc25C)/(cyclin-dependent kinase 1) CDK1 [536] proliferation signal

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Cell cycle was arrested with and without X-ray exposure In the without X-ray exposure condition (Fig

This protective nature of Cyperus esculentus nut is enhanced by some of its phytochemical constituents: the presence of ascorbic acid which is known for its protection on cell membranes and its scavenging effects on free radicals.58 Conclusion In conclusion NaF was found to induced reproductive dysfunction by alter spermatogenesis, induced testicular toxicity and cause infertility, intervention of Cyperus esculentus nut extract protected the cyto-architecture of the testis from the damaging effects of fluoride therefore Cyperus esculentus nut augments spermatogenesis, attenuates fluoride-induced oxidative stress through an antioxidant system of activities and promote fertility

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