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Ketamine and psilocybin each produce a brief acute experience but set off a wave of synaptic growth afterward, ketamine through glutamate release and mTOR-dependent synapse formation and psilocybin through rapid, lasting growth of dendritic spines in the frontal cortex, both via BDNF signaling, which is why a single session can shift symptoms for weeks

doi: 10.1152/physrev.00062.2017 58 DingF.YaoJ.RettbergJ

You may find certain places easier to reach and less sensitive than others

Medicine 98:e17518

Lets check a baseline TSH and repeat it in 48 weeks if we try it, and call sooner with new symptoms." It is brief, practical, and actionable

Sabrkhany, S., Griffioen, A