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This cycle is normally repeated only once every 6 months to allow the body to benefit from the cellular signaling without overstimulating the pineal gland

Passage of bile acids through the enterocyte activates FXR, which promotes the synthesis of fibroblast growth factor 19 (FGF19), which also circulates through the portal vein to the liver where it activates fibroblast growth factor-receptor 4 resulting in inhibition of bile acid synthesis

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Department of Defense has explicitly prohibited its use by Service Members