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Modern interest in NAD biology was reinvigorated by the 2000 discovery by Imai, Armstrong, Kaeberlein, and Guarente that the silent information regulator 2 (Sir2) family sirtuins are NAD-dependent protein deacylases, establishing a direct link between cellular NAD availability and gene-silencing, metabolic, and aging-related signaling pathways

These connections play a central role in how we learn and store memories

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Nov 13 2021;10(11)doi:10.3390/foods10112794

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Nrf2 is tightly regulated in numerous ways, among which phosphorylation by kinases plays a crucial role in the posttranslational regulation of Nrf2