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Lemon and orange juice are good sources of citrate, help alkalinize the urine, and appear to protect against kidney stones (UMMC 2013

PMID: 17664545

There are also no published guidelines for appropriate dosing regimes, or guidance for treatment duration when using this agent in this setting." There is unknown validity and some known adverse effects with IV GSH

Previous studies have revealed that PIK3CA mutations reprogram glutamine metabolism by upregulating the expression of glutamate pyruvate transaminase (GPT) 2, thereby increasing glutamine dependency in CRC cells [101]