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5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a small molecule that inhibits NNMT (nicotinamide N-methyltransferase), an enzyme that becomes overactive in metabolically aging tissue

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More serious but rare adverse events include pancreatitis (0.2% incidence), gallbladder disease requiring surgical intervention, and medullary thyroid carcinoma risk in genetically predisposed individuals (contraindicated in patients with personal or family history of MTC or MEN2 syndrome)

Epidemiological investigations have underscored a significant correlation between hyperlipidemia and conditions such as obesity or disruptions in energy metabolism (Zhu et al., 2016)

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The highest Loewe score in Be(2)-C is 45.3 and reached at ~1800 nM MitoQ combined with ~10 nM DPI ( Figure 2B )