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Although such efforts have yielded little success, more recent ploys incorporating specific and targeted payload delivery systems and techniques for upregulating transcription factors that activate specific genes encoding anti-oxidant enzymes are in progress (Poprac et al

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Med Assoc (2019) 118 Suppl:S1022

doi: 10.1111/j.1476-5381.2010.00729.x 234 GongJ-POnaiviESIshiguroHLiuQ-RTagliaferroPABruscoAet al

In a study of the combination of APR-246 and AZA for treating TP53-mutant MDS and AML, a control group receiving only AZA was included to assess the synergistic effects of the combination