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Interestingly, polymorphisms in genes encoding complement factors implicated in the risk of AMD and progression to GA do not necessarily influence the expansion of GA lesions and, in some cases, are even associated with slower lesion enlargement [24]

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To this end, beta values of the calibration samples were computed with the R/bioconductor package Minfi 71 (v.1.24.0), genomic locations of the array probes were mapped from GRCh37 to GRCh38 using the UCSC liftOver command line tool 72 , and probes within 250 base windows were averaged

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