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TB-500 (Thymosin Beta-4 fragment) has been investigated for its role in actin polymerization dynamics it sequesters G-actin monomers, regulating cytoskeletal organization critical for cell migration

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52 In a genetically engineered mouse model of CRC, mice bearing mutations in four genes commonly found in primary human cancers ( Apc fl/fl , Kras LSL-G12D , Tgfbr2 fl/fl and Trp53 fl/fl ) formed metastases