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Similarly, the largest survey of thiopurine-related toxicity in IBD patients reported to date, which included 3900 IBD patients treated with thiopurines from the Spanish ENEIDA Register [a nationwide register of IBD patients promoted by the Spanish Working Group in IBD (GETECCU)] found that both hepatotoxicity and acute pancreatitis were significantly more frequent in CD as compared to UC, although the smoking status information when starting thiopurines was not available[52]