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Prior to the fortification era, a case-control study showed that both red blood cell and serum folate concentrations were significantly lower in pregnant women with the T/T and C/T variants compared to the wild-type C/C genotype (24), suggesting inadequate folate metabolism with specific maternal genotypes

This raises some concern as one does not want to activate the immune system at the cost of enhancing monocyte adherence to endothelial cells

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A nice little summary table of important preclinical results helps bridge specific doses, models, and endpoints to a handy reference