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The need for diagnosis, treatment and prevention of AITD is also due to the need to prevent concomitant diseases, including disorders of the cardiovascular system, hypercholesterolemia, atrial fibrillation, encephalopathy, others autoimmune diseases ( Cellular and humoral immunity in the pathogenesis of AITD In addition to genetic, cellular and humoral immune mechanisms, loss of immune tolerance to thyroid autoantigens is the basis for the development of AITD

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Definition of cell senescence Although research on cell senescence lasts for decades, until recently, the field reached a consensus on the definition of cell senescence, that is, a type of cell state that can be stimulated by multiple stress signals throughout the life cycle and is characterized by cell cycle arrest, senescence-associated secretory phenotype (SASP), and dysregulated metabolism and macromolecular damage 1 (Fig