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Theranostic nuclear medicine with gallium-68, lutetium-177, copper-64/67, actinium-225, and lead-213/203 radionuclides

The FDA has recently made a public statement regarding Category 2 of bulk drug substances, focusing on Peptides

They can persistently alter the hosts antiviral defenses and disrupt cellular pathways that regulate liver homeostasis, ultimately leading to viral hepatitis and HCC development ( 2.1.1 The impact of selenium on HBV infection HBV infection is the cause of nearly 50% of HCC cases ( 2 SeO 3 ) can suppress HBV protein expression, transcription, and genome replication in a dose- and time-dependent manner in human hepatoma cell lines Huh7 and HepG2.2.15 ( M Na 2 SeO 3 can suppress HBV replication by ~50% in HepG2.2.15 cells by promoting apoptotic cell death and inhibiting cellular inhibitors of apoptosis proteins (cIAPs) ( Figure 1 )

Aberrant and diseased astrocytes promote death of motor neurones in amyotrophic lateral sclerosis, whereas loss of astrocyte homoeostatic support contributes to neuronal malfunction and demise in AD, PD, and HD

While the beneficial effects of actively removing toxic by-products of cellular insults, such as GSSG, via efflux pumps, have been well studied, the subsequent effects of these released by-products on neighboring cells and tissues are largely unknown

Funding AT is supported by a joint Pernicious Anaemia Society and University of Surrey studentship