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[PubMed abstract] Laird E, O'Halloran AM, Molloy AM, Healy M, Hernandez B, O'Connor D, Kenny RA, Briggs R

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It seems well-tolerated in available studies with low toxicity

This metabolic improvement occurs through AMPK pathway activation and increased NAD+-dependent SIRT1 activity, both of which enhance insulin receptor signaling and glucose metabolism