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The contribution of GHK versus 5-ALA to the observed effect cannot be isolated from this trial alone

Since the host-derived damage-associated molecular patterns (DAMPs), like bile acids, can directly engage GSDME to trigger pyroptosis, we reasoned that there might have certain endogenous metabolites capable of inhibiting GSDME activation

[32] Suo, L., VanBuren, C., Hovland, E.D., Kedishvili, N.Y., Sundberg, J.P., Everts, H.B