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Data were drift corrected during acquisition using a leucine encephalin ( m/z 556.2771) reference spray (Waters cop, #700008842) infused at 5 l min 1 , every 45 s

bias can be ruled out (9)

N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression