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10.17219/acem/171379 126 KwonK

To limit potentially life-threatening depletion of intracellular antioxidant/GSH stores, epithelial cells have developed numerous compensatory pathways, including the cystine-glutamate antiporter (SLC7A11), which critically maintains de novo GSH biosynthesis by increasing intracellular cystine levels (9)

Furthermore, autophagy may attenuate fibrosis and reduce hepatic injury by inhibiting inflammatory reaction and decreasing oxidative stress response (40)

A lack of glutathione would also negatively affect the liver and immune system

Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study

[DOI] [Google Scholar] Wu, D