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Among IL-22based therapies, the most extensively investigated agent is F-652, a recombinant fusion protein

NFIL3 (also known as E4BP4), a basic leucine zipper transcription factor, is a critical regulator of NK cell development through its induction of the transcriptional inhibitor Id2 (refs 33,34)

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Despite these advantages, peptide-based therapies face significant limitations

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