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Cancer 118:21382147 Sengupta S, Sobo M, Lee K, Senthil Kumar S, White AR, Mender I, Fuller C, Chow LM, Fouladi M, Shay JW (2018) Induced telomere damage to treat telomerase expressing therapy-resistant pediatric brain tumors

This approach may be particularly suitable for chronic inflammatory conditions where tissues need consistent support over extended periods

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NNMT is expressed abundantly in adipose tissue, where it has been associated with fat cell size and lipid storage dynamics

In Studies 1 and 2, all patients received a standard lifestyle intervention which included instruction on a reduced-calorie diet (approximately 500 kcal/day deficit) and increased physical activity counseling (recommended minimum of 150 min/week) that began with the first dose of study medication or placebo and continued throughout the trial

[DOI] [PMC free article] [PubMed] [Google Scholar] 244.Junk, D