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Normally the H 2 O 2 is then inactivated by glutathione peroxidase but it can be converted, chemically, by Fe 2+ ions (Fenton reaction) into the highly reactive hydroxyl radical

It blocks the synthesis of DNA, mRNA, and protein synthesis by interacting with purine bases on gDNA or mitochondrial DNA, inhibiting DNA replication and promoting cell apoptosis (57)

In the steady state there is no anemia, no evidence of increased red cell destruction, nor alteration in blood morphology

Glutathione is a powerful antioxidant naturally found in the human body, playing a crucial role in neutralizing free radicals, detoxifying harmful substances, and maintaining the immune system

Hybrid modeling of CHO cell cultivation in monoclonal antibody production with an impurity generation module

Biomed Pharmacother 156:113848 Wen J, Li A, Wang Z, Guo X, Zhang G, Litzow MR, Liu Q (2025) Hepatotoxicity induced by arsenic trioxide: clinical features, mechanisms, preventive and potential therapeutic strategies