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13 IB binds to NF-B through 38 ankyrin repeats at the C-terminus, masking the nuclear localization sequence (NLS) of NF-B and inhibiting its activity

The HFI series of compounds, e.g., 37 (HFI 419) identified in 2008 after the virtual screening are much more drug-like than the hexapeptides 11 (AL-11), 12 (IVDE77), and the potent macrocyclic Ang IV analogue 23 (HA08) and can hopefully after further systematic optimization be converted into bioactive small molecules with capacity to cross the blood-brain barrier

10.1016/j.cell.2012.03.042 37 Dos ReisL

It is also a common entry point for people who are curious but not ready for needles

AHK-Cu is also a potent skincare ingredient, working to rebuild and repair the skin by activating fibroblast and endothelial cell production