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A non-targeting siRNA was used as a control

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In the brain stroke, TRPM2 was shown to partake in I/R-induced neuronal apoptosis using TRPM2 knockout mice (Gelderblom et al., 2014)

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Mannitol decoration facilitated brain delivery through mannitol-mediated endothelial interactions and liposomal fusion, thereby enhancing transport across the bloodbrain barrier