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One plausible mechanism implicated in obesity-induced ASM remodeling involves the participation of HMGB1

Indeed, lower membranous PUFA content reduces fluidity, leading to cell death in a liver fibrosis model [48]

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These advances in metabolomics and systems biology hold the potential to enable the design of precision care approaches to the metabolic heterogeneity of type 2 diabetes and complications

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DNA methylation leads to DNA repair Gene Down-regulation and trinucleotide repeat expansion in patient-derived Huntington disease cells