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Hyperglycemia induces endoplasmic reticulum stress in atrial cardiomyocytes, and mitofusin-2 downregulation prevents mitochondrial dysfunction and subsequent cell death

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In the second model, the cells were subject to a heat shock treatment at 45 C in an incubator for 15 mins

J Mol Model 25:110 Guo R, Liu J, Chai J, Gao Y, Abdel-Rahman MA, Xu X (2022) Scorpion peptide Smp24 exhibits a potent antitumor effect on human lung cancer cells by damaging the membrane and cytoskeleton in vivo and in vitro

In this context, analyses using epigenetic risk scores indicate that DNA methylation patterns associated with chronic inflammation are associated with both the prevalence and incidence of depression ( Alterations in the GR gene and in the epigenetically sensitive regulators of GR play a significant role

2 Organ-on-chip in the 3D in vitro models framework OoCs allow researchers to model human diseases in the lab using immortalized or donor-derived cells cultured in organ-specific microenvironments