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PRP coverage varies by insurer and indication: some plans cover PRP for specific orthopedic conditions, but many consider it experimental

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No negative effects on carbohydrate metabolism

To the extent the data shows that there would be more than a limited impact on the relative weights initially, which we do not believe will be the case, CMS will be able to further consider the impact and appropriate approach to utilizing this market-based data in the MS-DRG relative weight methodology

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If the abovementioned is occurring, it could mean that IGF-1 administration could also lower glucose levels by suppressing hepatic gluconeogenesis, as well as improving insulin signalling in this organ, leading to IGFBP-1 suppression and overall improvement of the IGF-1/GH/insulin axis