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Stroke by Inducing HDAC9-dependent Deacetylation of HIF-1 and Sp1, Promotes TfR1 Transcription and GPX4 Reduction, Thus Determining Ferroptotic Neuronal Death

Mechanistically, GDIL binds and re-localizes the nuclear protein XRN2 to the cytoplasm, where GDIL further serve as a scaffold for XRN2 to identify and degrade CHAC1 mRNA

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However, this DOR mutant cannot internalize anymore when arrestin 3 expression is knocked-down suggesting that the non-phosphorylated DOR can internalize but in an arrestin 3-dependent manner

Interplay between lipid metabolism and autophagy