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We collected an integrated atlas of 273,923 single-cell transcriptomes and high-resolution spatial transcriptomic maps from muscles of young, old and geriatric mice (~5, 20 and 26 months old) at multiple time points following myotoxin injury

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However, a longer (nine months) duration of Grk2 knockdown was reported to lead to a nitric oxide-dependent vasodilation which overcomes vasoconstriction, making Grk2 +/ mice resistant to the development of hypertension [31]

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