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MDVs are transported to peroxisomes via the outer membrane mitochondrial anchoring protein ligase (MAPL) or are trafficked to lysosomes via the Parkin pathway, binding to lysosomes that degrade their cargoes [53]

Based on these findings, we hypothesize that ARID1As regulation of SLC7A11 transcription is dependent on SNF2L

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Conventional medical approaches to treating Parkinson's disease aim to replace the lost dopamine, but fall short of addressing the ongoing destruction of dopaminergic neurons

Another avenue is advanced surface engineering to create coatings that are selectively permeable to contaminants but act as a robust physical and chemical barrier to biological macromolecules, thus preventing the non-specific interactions that initiate toxicity.186 Fig