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Knig T, McBride HM (2024) Mitochondrial-derived vesicles in metabolism, disease, and aging

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doi: 10.3109/15360288.2012.679725 57 Lang-IllievichK.Bornemann-CimentiH

FIGURE 1 2.2.2 Disturbance of oxidative stress Oxidative stress refers to the imbalance between oxidation and antioxidant systems in the body, leading to excessive production of reactive oxygen species (ROS)

Different from the former studies, the Ala222Val variant exhibits identical catalytic properties as the wild-type enzyme, but it is thermolabile 17