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Another aspect of the invention pertains to treating an NNMT-expressing cancer, such as glioblastoma, by administering a therapeutically effective amount of one or more cations of the invention followed by administration of one or more cations chosen from Tables 3a and 3b

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A phase I/II study (NCT02514668) assessed the response to isatuximab monotherapy in daratumumab-refractory patients [77]

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Key finding: AOD 9604 reduced visceral fat by 38%, improved HOMA-IR by 52%, and corrected glucose intolerance (fasting glucose -28%)

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