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Due to the close proximity of the piriformis muscle to the low back area as well as the relation of the spinal nerves leaving the low back and then forming the large sciatic nerve (which, as explained above, passes near or through the piriformis muscle) this area needs to closely be assessed for its contribution to your dysfunction in the piriformis muscle

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Appetite Effects The question about appetite is interesting because the proposed mechanism could reasonably go either direction: Reduced lipogenesis and improved metabolic flexibility could produce secondary effects on appetite regulation NAD+ restoration has complex effects on hypothalamic appetite signaling Preclinical data do not consistently describe dramatic appetite changes In human use were it to become clinically available patient-reported appetite effects would be a relevant monitoring parameter, but the data do not currently support a strong a priori expectation