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MTHFR deficiencies lead to a shortage of the active form of folate within the body and negatively impacts the conversion of homocysteine to methionine

Nuclear NAD + is generated by nuclear NMNAT1 and is largely utilized by PARPs for DNA damage response and nuclear sirtuins such as SIRT1, SIRT6 or SIRT7 for epigenetic deacetylation 82,86

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Implications for Health and Lifespan Improving healthspan is directly associated with a decrease in cellular senescence, which presents the prospect of increasing life expectancy rather than merely life expectancy