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Down syndrome and the complexity of genome dosage imbalance

GSH depletion and oxidative stress reduce the expression of IL-1, TNF- and IL-6 in LPS-induced macrophages [42]

26 Three out of the five RCTs reviewed in this meta-analysis showed improvements in at least one cognitive function outcome measure, and pooled data from three trials showed a significant improvement in working memory, whilst improvements in processing speed failed to reach statistical significance