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(2016) Biochim Biophys Acta

Kihara et al

Although preclinical data are promising, clinical translation requires addressing NOs biphasic effects

The study was conducted in accordance with the Declaration of Helsinki, and the protocol was approved by the Medical Ethics Committee, Shanghai Changzheng Hospital

and the main findings of ferroptosiss promotion/inhibition of immunogenic cell death, remodeling effect on the tumour microenvironment, and synergistic effect of combination therapy, as well as the limitations of the experimental model (e.g., lack of clinical verification) and unresolved scientific questions

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