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The TRP-KYN Pathway and the Nervous System Besides TRP, some kynurenines, such as KYN, 3-HKYN, and ANA, primarily of hepatic and intestinal microbiota origin, cross the BBB and enter the TRP-KYN pathway

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Multiple preclinical and clinical studies showed that epigenetic mechanisms are involved in the pathophysiology and treatment of stress-related depressive and cognitive disorders